The term arthritis means "joint inflammation." Inflammation can cause pain, swelling, and stiffness. The two most common forms of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA).

Common Types of Arthritis

Osteoarthritis (OA) Adult Rheumatoid Arthritis (RA)
Develops when the cartilage (cushioning at the ends of bones) breaks down Develops when the body’s immune system attacks the joint
Causes pain and stiffness in the knees, hips, back, or hands Causes inflammation and severe pain in wrists, hands, and feet; also causes pain in neck, elbows, shoulders, knees, hips, and ankles
May cause significant pain and disability May also cause appetite loss, fever, lack of energy, anemia, or nodules (lumps) under the skin
Affects about 27 million Americans over the age of 25 Affects 1.3 million adults in the US, mostly women

Osteoarthritis
Osteoarthritis begins with the breakdown of joint cartilage, resulting in pain and stiffness. OA commonly affects the joints of the hips, knees, spine and fingers. Other joints affected less frequently include the wrists, elbows, shoulders, and ankles. OA can also be caused by work-related repetitive injury and physical trauma.

Rheumatoid Arthritis
Rheumatoid Arthritis causes inflammation of the joint lining, called the synovium. This type of arthritis can cause pain, stiffness, swelling, warmth, and redness. The affected joint may also lose its shape, resulting in loss of normal movement.

RA can affect other parts of the body as well, including the blood, the lungs, and the heart. Rheumatoid Arthritis is 2 to 3 times more common in women than in men, and generally affects people between the ages of 25 and 55. However, young children can develop a form of RA called juvenile RA.


Important Safety Information:

Like all prescription NSAIDs, CELEBREX may increase the chance of a heart attack or stroke that can lead to death. It should not be used right before or after certain heart surgeries.

Serious skin reactions or stomach and intestine problems, such as bleeding and ulcers, can occur without warning and may cause death.

Patients taking aspirin and the elderly are at increased risk for stomach bleeding and ulcers.

Tell your doctor if you:
* Are pregnant
* Have a history of ulcers or bleeding in the stomach or intestines
* Have high blood pressure or heart failure
* Have kidney or liver problems

People with aspirin-sensitive asthma or allergic reactions due to aspirin or other arthritis medicines or certain drugs called sulfonamides should not take CELEBREX.

Prescription CELEBREX should be used exactly as prescribed at the lowest dose possible and for the shortest time needed.

For more information about CELEBREX and other NSAIDs, please see the Medication Guide.
For further information on CELEBREX, please see the full Prescribing Information.

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