The term arthritis means "joint inflammation." Inflammation can cause pain, swelling, and stiffness. The two most common forms of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA).

Common Types of Arthritis

Osteoarthritis (OA) Adult Rheumatoid Arthritis (RA)
Develops when the cartilage (cushioning at the ends of bones) breaks down Develops when the body’s immune system attacks the joint
Causes pain and stiffness in the knees, hips, back, or hands Causes inflammation and severe pain in wrists, hands, and feet; also causes pain in neck, elbows, shoulders, knees, hips, and ankles
May cause significant pain and disability May also cause appetite loss, fever, lack of energy, anemia, or nodules (lumps) under the skin
Affects about 27 million Americans over the age of 25 Affects 1.3 million adults in the US, mostly women

Osteoarthritis
Osteoarthritis begins with the breakdown of joint cartilage, resulting in pain and stiffness. OA commonly affects the joints of the hips, knees, spine and fingers. Other joints affected less frequently include the wrists, elbows, shoulders, and ankles. OA can also be caused by work-related repetitive injury and physical trauma.

Rheumatoid Arthritis
Rheumatoid Arthritis causes inflammation of the joint lining, called the synovium. This type of arthritis can cause pain, stiffness, swelling, warmth, and redness. The affected joint may also lose its shape, resulting in loss of normal movement.

RA can affect other parts of the body as well, including the blood, the lungs, and the heart. Rheumatoid Arthritis is 2 to 3 times more common in women than in men, and generally affects people between the ages of 25 and 55. However, young children can develop a form of RA called juvenile RA.


Indications:

CELEBREX is indicated for the relief of the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, and for the management of acute pain in adults.

Important Safety Information:

Like all prescription NSAIDs, CELEBREX may increase the chance of heart attack or stroke that can lead to death. This chance increases if you have heart disease or risk factors for it, such as high blood pressure or when NSAIDs are taken for long periods.

CELEBREX should not be used right before or after certain heart surgeries.

Serious skin reactions, or stomach and intestine problems such as bleeding and ulcers, can occur without warning and may cause death. Patients taking aspirin and the elderly are at increased risk for stomach bleeding and ulcers.

Tell your doctor if you have:
* A history of ulcers or bleeding in the stomach or intestines
* High blood pressure or heart failure
* Kidney or liver problems

CELEBREX should not be taken in late pregnancy.

Do not take CELEBREX if you've had an asthma attack, hives, or other allergic reactions to aspirin, any other NSAID medicine, or certain drugs called sulfonamides.

Life threatening allergic reactions can occur with CELEBREX. Get help right away if you've had swelling of the face or throat or trouble breathing.

Prescription CELEBREX should be used exactly as prescribed at the lowest dose possible and for the shortest time needed.

For more information about CELEBREX and other NSAIDs, please see the Medication Guide.
For further information on CELEBREX, please see the full Prescribing Information.

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